Map1b (基因名), Microtubule-associated protein 1B (蛋白名), map1b_rat.
产品名称:
Rat Map1b/ Microtubule-associated protein 1B CLIA Kit
微管相关蛋白1b
货号:
U9938r
商标:
EIAab®
监管等级:
别名:
Neuraxin, MAP-1B
检测方法:
CLIA
特异性:
Natural and recombinant rat Microtubule-associated protein 1B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2. Interacts with the tubulin tyrosine TTL (By similarity). Interacts (via C-terminus) with GAN (via Kelch domains). Interacts (via N-terminus) with DAPK1. Interacts with TMEM185A. Interacts with MAP1LC3B. Interacts with KIRREL3.
功能:
Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation (By similarity). Interacts with TMEM185A.
亚细胞位置:
Cytoplasm
Cytoskeleton
Cytoplasm
Cell junction
Synapse
Cell projection
Dendritic spine
Colocalizes with DAPK1 in the microtubules and cortical actin fibers.
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