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PI3K-Akt Pathway

The serine/threonine kinase Akt acts as a proto-oncogene that plays an important role in the regulation of various cellular functions including metabolism, growth, proliferation, survival, transcription, and protein synthesis. Factors that activate the Akt signaling cascade, including receptor tyrosine kinases, integrins, B-cell and T-cell receptors, cytokine receptors, G-protein coupled receptors, and others capable of passing phosphatidylinositol III Kinase (PI3K) induces stimulation of triphosphate phosphatidylinositol (PIP3) production. Direct binding of Ras and p110 can activate PI3K.Activated PI3K produces PIP3.PIP3 binds to the PH domain-containing signaling protein Akt and PDK1, alters the protein structure of Akt, and translocates it to the cell membrane, allowing protein phosphorylation of PDK21 and PDK-2 on the membrane. Phosphorylation of PDK1 leads to Akt activation. Activated Akt activates or inhibits a series of downstream substrates such as Bad, caspase 9, NF-κB, GSK23 , thereby regulating cell proliferation, differentiation, apoptosis and migration.
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Alternative:
Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha,PKB,RAC
Detection Range:
0.78-50ng/mL
Sensitivity:
0.195ng/mL
Assay Type:
Sandwich
Cat.#: E0382h
AKT1, E0382h ×
Package
Quantity
Price ($)

48T
0.00 / 515.20
96T
0.00 / 736.00
5x96T
0.00 / 2944.00
10x96T
0.00 / 4416.00
50x96T
0.00 / 12880.00
Discount: 0.0
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Human AKT1 ELISA Kit
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Alternative:
AKT1 kinase,Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha,Thymoma viral proto-oncogene,Akt,Rac
Detection Range:
0.312-20ng/mL
Sensitivity:
0.173ng/mL
Assay Type:
Sandwich
Cat.#: E0382m
Akt1, E0382m ×
Package
Quantity
Price ($)

48T
0.00 / 543.20
96T
0.00 / 776.00
5x96T
0.00 / 3104.00
10x96T
0.00 / 4656.00
50x96T
0.00 / 13580.00
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Mouse Akt1 ELISA Kit
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Alternative:
AKT1 kinase,Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha,Thymoma viral proto-oncogene,Akt,Rac
Detection Range:
39-2500pg/mL
Sensitivity:
-
Assay Type:
Sandwich
Cat.#: U0382m
Akt1, U0382m ×
Package
Quantity
Price ($)

48T
0.00 / 543.20
96T
0.00 / 776.00
5x96T
0.00 / 3104.00
10x96T
0.00 / 4656.00
50x96T
0.00 / 13580.00
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Mouse Akt1 CLIA Kit
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Alternative:
Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,RAC-PK-alpha
Detection Range:
0.156-10ng/ml
Sensitivity:
0.078ng/mL
Assay Type:
Sandwich
Cat.#: E0382r
Akt1, E0382r ×
Package
Quantity
Price ($)

48T
0.00 / 557.20
96T
0.00 / 796.00
5x96T
0.00 / 3184.00
10x96T
0.00 / 4776.00
50x96T
0.00 / 13930.00
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Rat Akt1 ELISA Kit
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Alternative:
BAD,Bcl-2-binding component 6,Bcl-2-like protein 8,Bcl2-L-8,Bcl-xL/Bcl-2-associated death promoter,Bcl2 antagonist of cell death,BBC6,BCL2L8
Detection Range:
0.156-10ng/mL
Sensitivity:
0.098ng/ml
Assay Type:
Sandwich
Cat.#: E15040h
BAD, E15040h ×
Package
Quantity
Price ($)

48T
0.00 / 515.20
96T
0.00 / 736.00
5x96T
0.00 / 2944.00
10x96T
0.00 / 4416.00
50x96T
0.00 / 12880.00
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Human BAD ELISA Kit
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Alternative:
BCR-associated protein 31,6C6-AG tumor-associated antigen,Protein CDM,p28,BAP31,DXS1357E
Detection Range:
0.156-10ng/mL
Sensitivity:
0.078ng/mL
Assay Type:
Sandwich
Cat.#: E14114h
BCAP31, E14114h ×
Package
Quantity
Price ($)

48T
0.00 / 515.20
96T
0.00 / 736.00
5x96T
0.00 / 2944.00
10x96T
0.00 / 4416.00
50x96T
0.00 / 12880.00
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Human BCAP31 ELISA Kit
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Alternative:
BCR-associated protein 31,p28,Bap31
Detection Range:
0.156-10ng/mL
Sensitivity:
0.078ng/mL
Assay Type:
Sandwich
Cat.#: E14114m
Bcap31, E14114m ×
Package
Quantity
Price ($)

48T
0.00 / 543.20
96T
0.00 / 776.00
5x96T
0.00 / 3104.00
10x96T
0.00 / 4656.00
50x96T
0.00 / 13580.00
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Mouse Bcap31 ELISA Kit
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Alternative:
B-lymphocyte surface antigen B4,Differentiation antigen CD19,T-cell surface antigen Leu-12,CD19
Detection Range:
1.56-100ng/mL
Sensitivity:
0.66ng/mL
Assay Type:
Sandwich
Cat.#: E1873h
CD19, E1873h ×
Package
Quantity
Price ($)

48T
0.00 / 515.20
96T
0.00 / 736.00
5x96T
0.00 / 2944.00
10x96T
0.00 / 4416.00
50x96T
0.00 / 12880.00
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Human CD19 ELISA Kit
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Alternative:
B-lymphocyte surface antigen B4,Differentiation antigen CD19,T-cell surface antigen Leu-12,CD19
Detection Range:
0.195-12.5ng/mL
Sensitivity:
-
Assay Type:
Sandwich
Cat.#: U1873h
CD19, U1873h ×
Package
Quantity
Price ($)

48T
0.00 / 515.20
96T
0.00 / 736.00
5x96T
0.00 / 2944.00
10x96T
0.00 / 4416.00
50x96T
0.00 / 12880.00
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Human CD19 CLIA Kit
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Alternative:
Differentiation antigen CD19,CD19
Detection Range:
1.25-80ng/mL
Sensitivity:
0.633ng/mL
Assay Type:
Sandwich
Cat.#: E1873m
Cd19, E1873m ×
Package
Quantity
Price ($)

48T
0.00 / 543.20
96T
0.00 / 776.00
5x96T
0.00 / 3104.00
10x96T
0.00 / 4656.00
50x96T
0.00 / 13580.00
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Mouse Cd19 ELISA Kit
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Alternative:
59 kDa serine/threonine-protein kinase,ILK-1,ILK-2,p59ILK,ILK1,ILK2
Detection Range:
0.78-50ng/mL
Sensitivity:
0.401ng/mL
Assay Type:
Sandwich
Cat.#: E1587h
ILK, E1587h ×
Package
Quantity
Price ($)

48T
0.00 / 515.20
96T
0.00 / 736.00
5x96T
0.00 / 2944.00
10x96T
0.00 / 4416.00
50x96T
0.00 / 12880.00
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Human ILK ELISA Kit
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Alternative:
-
Detection Range:
0.625-40ng/mL
Sensitivity:
0.312ng/mL
Assay Type:
Sandwich
Cat.#: E1587m
Ilk, E1587m ×
Package
Quantity
Price ($)

48T
0.00 / 543.20
96T
0.00 / 776.00
5x96T
0.00 / 3104.00
10x96T
0.00 / 4656.00
50x96T
0.00 / 13580.00
Discount: 0.0
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Mouse Ilk ELISA Kit
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Alternative:
-
Detection Range:
0.156-10ng/ml
Sensitivity:
0.078ng/mL
Assay Type:
Sandwich
Cat.#: E1587r
Ilk, E1587r ×
Package
Quantity
Price ($)

48T
0.00 / 557.20
96T
0.00 / 796.00
5x96T
0.00 / 3184.00
10x96T
0.00 / 4776.00
50x96T
0.00 / 13930.00
Discount: 0.0
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Rat Ilk ELISA Kit
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Alternative:
IRS-1
Detection Range:
0.312-20ng/mL
Sensitivity:
0.168ng/mL
Assay Type:
Sandwich
Cat.#: E1660h
IRS1, E1660h ×
Package
Quantity
Price ($)

48T
0.00 / 515.20
96T
0.00 / 736.00
5x96T
0.00 / 2944.00
10x96T
0.00 / 4416.00
50x96T
0.00 / 12880.00
Discount: 0.0
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Human IRS1 ELISA Kit
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Alternative:
IRS-1,Irs-1
Detection Range:
0.312-20ng/mL
Sensitivity:
0.171ng/mL
Assay Type:
Sandwich
Cat.#: E1660m
Irs1, E1660m ×
Package
Quantity
Price ($)

48T
0.00 / 543.20
96T
0.00 / 776.00
5x96T
0.00 / 3104.00
10x96T
0.00 / 4656.00
50x96T
0.00 / 13580.00
Discount: 0.0
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Mouse Irs1 ELISA Kit
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Package & Price:
Alternative:
IRS-1,pp185,Irs-1
Detection Range:
39-2500pg/mL
Sensitivity:
-
Assay Type:
Sandwich
Cat.#: U1660r
Irs1, U1660r ×
Package
Quantity
Price ($)

48T
0.00 / 557.20
96T
0.00 / 796.00
5x96T
0.00 / 3184.00
10x96T
0.00 / 4776.00
50x96T
0.00 / 19390.00
Discount: 0.0
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Rat Irs1 CLIA Kit
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Package & Price:
Alternative:
IRS-1,pp185,Irs-1
Detection Range:
0.312-20ng/mL
Sensitivity:
0.174ng/mL
Assay Type:
Sandwich
Cat.#: E1660r
Irs1, E1660r ×
Package
Quantity
Price ($)

48T
0.00 / 557.20
96T
0.00 / 796.00
5x96T
0.00 / 3184.00
10x96T
0.00 / 4776.00
50x96T
0.00 / 13930.00
Discount: 0.0
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Rat Irs1 ELISA Kit
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Alternative:
GPalpha IIb,GPIIb,Platelet membrane glycoprotein IIb,CD41,GP2B,ITGAB
Detection Range:
0.156-10ng/mL
Sensitivity:
0.1ng/mL
Assay Type:
Sandwich
Cat.#: E0614h
ITGA2B, E0614h ×
Package
Quantity
Price ($)

48T
0.00 / 515.20
96T
0.00 / 736.00
5x96T
0.00 / 2944.00
10x96T
0.00 / 4416.00
50x96T
0.00 / 12880.00
Discount: 0.0
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Human ITGA2B ELISA Kit
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Alternative:
GPalpha IIb,GPIIb,Platelet membrane glycoprotein IIb,CD41
Detection Range:
0.312-20ng/mL
Sensitivity:
0.156ng/mL
Assay Type:
Sandwich
Cat.#: E0614m
Itga2b, E0614m ×
Package
Quantity
Price ($)

48T
0.00 / 543.20
96T
0.00 / 776.00
5x96T
0.00 / 3104.00
10x96T
0.00 / 4656.00
50x96T
0.00 / 13580.00
Discount: 0.0
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Mouse Itga2b ELISA Kit
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Package & Price:
Alternative:
GPalpha IIb,GPIIb,Platelet membrane glycoprotein IIb,CD41
Detection Range:
39-2500pg/mL
Sensitivity:
-
Assay Type:
Sandwich
Cat.#: U0614m
Itga2b, U0614m ×
Package
Quantity
Price ($)

48T
0.00 / 543.20
96T
0.00 / 776.00
5x96T
0.00 / 3104.00
10x96T
0.00 / 4656.00
50x96T
0.00 / 13580.00
Discount: 0.0
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Mouse Itga2b CLIA Kit
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