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AKT Pathway

The serine/threonine kinase Akt acts as a proto-oncogene that plays an important role in the regulation of various cellular functions including metabolism, growth, proliferation, survival, transcription, and protein synthesis. Factors that activate the Akt signaling cascade, including receptor tyrosine kinases, integrins, B-cell and T-cell receptors, cytokine receptors, G-protein coupled receptors, and others capable of passing phosphatidylinositol III Kinase (PI3K) induces stimulation of triphosphate phosphatidylinositol (PIP3) production.

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