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MAP1B (基因名), Microtubule-associated protein 1B (蛋白名), map1b_human.
产品名称:

Human MAP1B/ Microtubule-associated protein 1B ELISA Kit
微管相关蛋白1b

货号:

E9938h

商标:
EIAab®
监管等级:
别名:

MAP-1B

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.086ng/mL
特异性:
Natural and recombinant human Microtubule-associated protein 1B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Human MAP1B ELISA Kit
规格 & 价格: cart
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Human MAP1B ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2. Interacts with the tubulin tyrosine TTL (By similarity). Interacts (via C-terminus) with GAN (via Kelch domains) (PubMed:12147674, PubMed:16227972). Interacts (via N-terminus) with DAPK1 (PubMed:18195017). Interacts with TMEM185A (PubMed:15525354). Interacts with MAP1LC3B (PubMed:24089205). Interacts with KIRREL3 (PubMed:25902260).


功能:
Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.


亚细胞位置:
Cytoplasm Cytoskeleton Cytoplasm Cell junction Synapse Cell projection Dendritic spine Colocalizes with DAPK1 in the microtubules and cortical actin fibers.


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