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MAP1B (基因名), Microtubule-associated protein 1B (蛋白名), map1b_human.
产品名称:

Human MAP1B/ Microtubule-associated protein 1B Recombinant Protein
微管相关蛋白1b

货号:

R9938h

商标:
EIAab®
监管等级:
别名:

MAP-1B

序列号:
P46821
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MAP1B Protein
规格 & 价格: cart
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Human MAP1B Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 5q13.2 by HGNC 5q13.2 by Entrez Gene 5q13.2 by Ensembl
MAP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2. Interacts with the tubulin tyrosine TTL (By similarity). Interacts (via C-terminus) with GAN (via Kelch domains) (PubMed:12147674, PubMed:16227972). Interacts (via N-terminus) with DAPK1 (PubMed:18195017). Interacts with TMEM185A (PubMed:15525354). Interacts with MAP1LC3B (PubMed:24089205). Interacts with KIRREL3 (PubMed:25902260).


功能:
Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.


亚细胞位置:
Cytoplasm Cytoskeleton Cytoplasm Cell junction Synapse Cell projection Dendritic spine Colocalizes with DAPK1 in the microtubules and cortical actin fibers.


该产品尚未在任何出版物中被引用。

[1].
"DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing."

[2].
"Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region."

[3].
"Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15."

[4].
"Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13."

[5].
"Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment."
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