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MAP1B (基因名), Microtubule-associated protein 1B (蛋白名), map1b_human.

产品名称:

Human MAP1B/ Microtubule-associated protein 1B CLIA Kit
微管相关蛋白1b

货号:

U9938h

商标:

EIAab^®

监管等级:

RUO

别名:

MAP-1B

检测方法:

CLIA

特异性:

Natural and recombinant human Microtubule-associated protein 1B

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human MAP1B CLIA Kit

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通用注释

亚单元:

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2. Interacts with the tubulin tyrosine TTL (By similarity). Interacts (via C-terminus) with GAN (via Kelch domains) (PubMed:12147674, PubMed:16227972). Interacts (via N-terminus) with DAPK1 (PubMed:18195017). Interacts with TMEM185A (PubMed:15525354). Interacts with MAP1LC3B (PubMed:24089205). Interacts with KIRREL3 (PubMed:25902260).

功能:

Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.

亚细胞位置:

Cytoplasm Cytoskeleton Cytoplasm Cell junction Synapse Cell projection Dendritic spine Colocalizes with DAPK1 in the microtubules and cortical actin fibers.

数据库链接

UniGene:

Hs.335079

STRING:

9606.ENSP00000296755

KEGG:

hsa:4131

MIM:

157129

Pfam:

PF00414

Uniprot:

P46821

相关产品

Mouse Map1b ELISA Kit

序列长度:

2468

序列:

仅供参考，详细请咨询（services@eiaab.com）

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SSTVVMQDES | FPACKIEL

3D 模型:

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Human MAP1B/ Microtubule-associated protein 1B CLIA Kit 微管相关蛋白1b

U9938h

MAP-1B

Human MAP1B/ Microtubule-associated protein 1B CLIA Kit
微管相关蛋白1b