首页 > 重组蛋白 > Human YTHDC1 Recombinant Protein

YTHDC1 (基因名), YTH domain-containing protein 1 (蛋白名), ytdc1_human.

产品名称:

Human YTHDC1/ YTH domain-containing protein 1 Recombinant Protein
YTH结构域蛋白1

货号:

R7767h

商标:

EIAab^®

监管等级:

RUO

别名:

Splicing factor YT521, YT521-B, KIAA1966, YT521

序列号:

Q96MU7

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Epigenetics

规格 & 价格:

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Human YTHDC1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 4q13.2 by HGNC 4q13.2 by Entrez Gene 4q13.2 by Ensembl

YTHDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with KHDRBS1/SAM68 (By similarity). Interacts with SRSF1 (By similarity). Interacts with SRSF2 (By similarity). Interacts with TRA2B (By similarity). Interacts with SRSF3 (PubMed:26876937). Interacts with SRSF10 (PubMed:26876937). Interacts with KHDRBS3 (By similarity). Interacts with EMD (PubMed:12755701). Interacts with RBMX (PubMed:19282290).

功能:

Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602).

亚细胞位置:

Nucleus Nucleus speckle Localizes to a novel subnuclear structure, the YT bodies.

数据库链接

UniGene:

Hs.175955

SMR:

Q96MU7

STRING:

9606.ENSP00000339245

KEGG:

hsa:91746

Pfam:

PF04146

Uniprot:

Q96MU7

相关产品

Mouse Ythdc1 ELISA Kit

Rat Ythdc1 ELISA Kit

Mouse Ythdc1 CLIA Kit

Rat Ythdc1 CLIA Kit

Mouse Ythdc1 Protein

序列长度:

727

序列:

仅供参考，详细请咨询（services@eiaab.com）

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727:

RGRDRERERE | RLCDRDRDRG | ERGRYRR

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Emerin interacts in vitro with the splicing-associated factor, YT521-B."

(PMID: 12755701)

[2].

"YTH: a new domain in nuclear proteins."

(PMID: 12368078)

[3].

"YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs."

(PMID: 28984244)

[4].

"m(6)A RNA methylation promotes XIST-mediated transcriptional repression."

(PMID: 27602518)

[5].

"Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing."

(PMID: 26876937)

[6].

"Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins."

(PMID: 26318451)

[7].

"Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain."

(PMID: 25242552)

[8].

"The YTH domain is a novel RNA binding domain."

(PMID: 20167602)

[9].

"Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA."

(PMID: 19282290)

[10].

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."

(PMID: 17081983)

[1].

人YTH结构域蛋白1(YTHDC1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人YTH结构域蛋白1(YTHDC1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人YTH结构域蛋白1(YTHDC1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人YTH结构域蛋白1(YTHDC1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人YTH结构域蛋白1(YTHDC1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人YTH结构域蛋白1(YTHDC1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人YTH结构域蛋白1(YTHDC1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人YTH结构域蛋白1(YTHDC1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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