Ythdc1 (基因名), YTH domain-containing protein 1 (蛋白名), ytdc1_rat.
产品名称:
Rat Ythdc1/ YTH domain-containing protein 1 CLIA Kit
YTH结构域蛋白1
货号:
U7767r
商标:
EIAab®
监管等级:
别名:
RA301-binding protein, Splicing factor YT521, Yt521
检测方法:
CLIA
特异性:
Natural and recombinant rat YTH domain-containing protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Epigenetics
通用注释
亚单元:
Interacts with KHDRBS1/SAM68 (PubMed:10564280). Interacts with SRSF1 (PubMed:10564280). Interacts with SRSF2 (PubMed:10564280). Interacts with SRSF3. Interacts with TRA2B (PubMed:10564280). Interacts with SRSF10 (By similarity). Interacts with KHDRBS3 (PubMed:11118435). Interacts with EMD (By similarity). Interacts with RBMX (PubMed:10564280).
功能:
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and acts as a regulator of alternative splicing (PubMed:25389274). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25389274). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (By similarity). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (By similarity). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity). May also regulate alternative splice site selection (PubMed:10564280, PubMed:9473574).
亚细胞位置:
Nucleus
Nucleus speckle
Localizes to a novel subnuclear structure, the YT bodies.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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