Ythdc1 (基因名), YTH domain-containing protein 1 (蛋白名), ytdc1_mouse.
产品名称:
Mouse Ythdc1/ YTH domain-containing protein 1 CLIA Kit
YTH结构域蛋白1
货号:
U7767m
商标:
EIAab®
监管等级:
别名:
Kiaa1966
检测方法:
CLIA
特异性:
Natural and recombinant mouse YTH domain-containing protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Epigenetics
通用注释
亚单元:
Interacts with KHDRBS1/SAM68 (By similarity). Interacts with SRSF1 (By similarity). Interacts with SRSF2 (By similarity). Interacts with TRA2B (By similarity). Interacts with SRSF3 (By similarity). Interacts with SRSF10 (By similarity). Interacts with KHDRBS3 (By similarity). Interacts with EMD (By similarity). Interacts with RBMX.
功能:
Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10. Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May also regulate alternative splice site selection.
亚细胞位置:
Nucleus
Nucleus speckle
Localizes to a novel subnuclear structure, the YT bodies.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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