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Lamp2 (基因名), Lysosome-associated membrane glycoprotein 2 (蛋白名), lamp2_mouse.
产品名称:

Mouse Lamp2/ Lysosome-associated membrane glycoprotein 2 ELISA Kit
溶酶体相关膜糖蛋白2

货号:

E1464m

商标:
EIAab®
监管等级:
别名:

CD107 antigen-like family member B, Lysosomal membrane glycoprotein type B, LGP-B, CD107b, LAMP-2, Lamp-2

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.312-20ng/mL
灵敏度:
0.182ng/mL
特异性:
Natural and recombinant mouse Lysosome-associated membrane glycoprotein 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cardiovascular
Mouse Lamp2 ELISA Kit
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Mouse Lamp2 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Monomer. Forms large homooligomers. Interacts (via its cytoplasmic region) with HSPA8. Interacts with HSP90 in the lysosome lumen; this enhances LAMP2 stability (By similarity). Interacts with MLLT11.


功能:
Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:10972293). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:10972293, PubMed:12221139). Plays a role in lysosomal protein degradation in response to starvation (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits. Is not required for efficient MHCII-mediated presentation of endogenous antigens.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Endosome membrane Single-pass type I membrane protein Cytoplasmic vesicle Autophagosome membrane Lysosome membrane Single-pass type I membrane protein This protein shuttles between lysosomes, endosomes, and the plasma membrane.


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