Lamp2 (基因名), Lysosome-associated membrane glycoprotein 2 (蛋白名), lamp2_rat.
产品名称:
Rat Lamp2/ Lysosome-associated membrane glycoprotein 2 CLIA Kit
溶酶体相关膜糖蛋白2
货号:
U1464r
商标:
EIAab®
监管等级:
别名:
CD107 antigen-like family member B, LGP-110, LGP-96, Lysosomal membrane glycoprotein type B, LGP-B, CD107b, LAMP-2, Lamp-2
检测方法:
CLIA
特异性:
Natural and recombinant rat Lysosome-associated membrane glycoprotein 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cardiovascular
通用注释
亚单元:
Monomer (PubMed:18644871). Forms large homooligomers (PubMed:11082038, PubMed:18644871). Interacts (via its cytoplasmic region) with HSPA8 (PubMed:18644871). Interacts with HSP90 in the lysosome lumen; this enhances LAMP2 stability (PubMed:18644871). Interacts with MLLT11.
功能:
Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038). Binds target proteins, such as GAPDH, and targets them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871). Plays a role in lysosomal protein degradation in response to starvation (PubMed:11082038). Required for the fusion of autophagosomes with lysosomes during autophagy. Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes. Required for normal degradation of the contents of autophagosomes. Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits. Is not required for efficient MHCII-mediated presentation of endogenous antigens.
亚细胞位置:
Cell membrane
Single-pass type I membrane protein
Endosome membrane
Single-pass type I membrane protein
Lysosome membrane
Single-pass type I membrane protein
Cytoplasmic vesicle
Autophagosome membrane
This protein shuttles between lysosomes, endosomes, and the plasma membrane.
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