FOXO3 (基因名), Forkhead box protein O3 (蛋白名), foxo3_human.
产品名称:
Human FOXO3/ Forkhead box protein O3 CLIA Kit
叉头框蛋白O3
货号:
U0762h
商标:
EIAab®
监管等级:
别名:
AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1, FKHRL1, FOXO3A
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
39-2500pg/mL
特异性:
Natural and recombinant human Forkhead box protein O3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Interacts with SIRT2; the interaction occurs independently of SIRT2 deacetylase activity (By similarity). Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration (PubMed:16751106). Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation (PubMed:16751106). Interacts with PIM1 (PubMed:18593906). Interacts with DDIT3/CHOP (PubMed:22761832). Interacts (deacetylated form) with SKP2 (PubMed:21841822). Interacts with CHUK and IKBKB (PubMed:15084260, PubMed:22313691). Interacts with CAMK2A, CAMK2B and calcineurin A.
功能:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
亚细胞位置:
Cytoplasm
Cytosol
Nucleus
Retention in the cytoplasm contributes to its inactivation. Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
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