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Foxo3 (基因名), Forkhead box protein O3 (蛋白名), foxo3_mouse.
产品名称:

Mouse Foxo3/ Forkhead box protein O3 ELISA Kit
叉头框蛋白O3

货号:

E0762m

商标:
EIAab®
监管等级:
别名:

Fkhr2, Foxo3a

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
31.2-2000pg/mL
灵敏度:
15.6pg/mL
特异性:
Natural and recombinant mouse Forkhead box protein O3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Mouse Foxo3 ELISA Kit
规格 & 价格: cart
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Mouse Foxo3 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with SIRT2; the interaction occurs independently of SIRT2 deacetylase activity (PubMed:17521387). Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1. Interacts with DDIT3/CHOP. Interacts (deacetylated form) with SKP2. Interacts with CHUK and IKBKB (By similarity). Interacts with CAMK2A, CAMK2B and calcineurin A (PubMed:23805378).


功能:
Transcriptional activator (PubMed:23805378). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.


亚细胞位置:
Cytoplasm Cytosol Nucleus Retention in the cytoplasm contributes to its inactivation. Translocates to the nucleus upon oxidative stress and in the absence of survival factors.


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