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Foxo3 (基因名), Forkhead box protein O3 (蛋白名), foxo3_mouse.
产品名称:

Mouse Foxo3/ Forkhead box protein O3 Recombinant Protein
叉头框蛋白O3

货号:

R0762m

商标:
EIAab®
监管等级:
别名:

Fkhr2, Foxo3a

序列号:
Q9WVH4
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Mouse Foxo3 Protein
规格 & 价格: cart
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Mouse Foxo3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Interacts with SIRT2; the interaction occurs independently of SIRT2 deacetylase activity (PubMed:17521387). Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1. Interacts with DDIT3/CHOP. Interacts (deacetylated form) with SKP2. Interacts with CHUK and IKBKB (By similarity). Interacts with CAMK2A, CAMK2B and calcineurin A (PubMed:23805378).


功能:
Transcriptional activator (PubMed:23805378). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.


亚细胞位置:
Cytoplasm Cytosol Nucleus Retention in the cytoplasm contributes to its inactivation. Translocates to the nucleus upon oxidative stress and in the absence of survival factors.


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