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IGF2R (基因名), Cation-independent mannose-6-phosphate receptor (蛋白名), MPRI_HUMAN.
产品名称:

Human IGF2R/ Cation-independent mannose-6-phosphate receptor Recombinant Protein
CIMan-6-Preceptor

货号:

R1629h

商标:
EIAab®
监管等级:
别名:

300 kDa mannose 6-phosphate receptor, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, M6P/IGF2 receptor, MPR 300, IGF-II receptor, M6P/IGF2R, CD222, CI Man-6-P receptor, MPRI

序列号:
P11717
来源:
E.coli
种属:
Human
标签:
His
序列:
2328-2491aa
预估分子量:
18.04 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human IGF2R Protein
规格 & 价格: cart
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Human IGF2R Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
Human IGF2R Protein
Recombinant human IGF2R protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 6q25.3 by HGNC 6q25.3 by Entrez Gene 6q25.3 by Ensembl
IGF2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3.


功能:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.


亚细胞位置:
Lysosome membrane Single-pass type I membrane protein Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.


该产品尚未在任何出版物中被引用。

[1].
"IGF2R missense single-nucleotide polymorphisms and breast cancer risk: the multiethnic cohort study."

[2].
"The 3' UTR IGF2R-A2/B2 variant is associated with increased tumor growth and advanced stages in non-small cell lung cancer."

[3].
"Structure and functional analysis of the IGF-II/IGF2R interaction."

[4].
"Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood height."

[5].
"Lack of association of birth size with polymorphisms of two imprinted genes, IGF2R and GRB10."
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