IGF2R (基因名), Cation-independent mannose-6-phosphate receptor (蛋白名), mpri_bovin.
产品名称:
Bovine IGF2R/ Cation-independent mannose-6-phosphate receptor CLIA Kit
CIMan-6-Preceptor
货号:
U1629b
商标:
EIAab®
监管等级:
别名:
300 kDa mannose 6-phosphate receptor, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, MPR 300, IGF-II receptor, CD222, CI Man-6-P receptor, M6P
检测方法:
CLIA
特异性:
Natural and recombinant bovine Cation-independent mannose-6-phosphate receptor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
Immunology
通用注释
亚单元:
Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3 (By similarity). Binds HA-I and HA-II plasma membrane adapters.
功能:
Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.
亚细胞位置:
Lysosome membrane
Single-pass type I membrane protein
Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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