IGF2R (基因名), Cation-independent mannose-6-phosphate receptor (蛋白名), mpri_human.
产品名称:
Human IGF2R/ Cation-independent mannose-6-phosphate receptor CLIA Kit
CIMan-6-Preceptor
货号:
U1629h
商标:
EIAab®
监管等级:
别名:
300 kDa mannose 6-phosphate receptor, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, M6P/IGF2 receptor, MPR 300, IGF-II receptor, M6P/IGF2R, CD222, CI Man-6-P receptor, MPRI
检测方法:
CLIA
特异性:
Natural and recombinant human Cation-independent mannose-6-phosphate receptor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Immunology
通用注释
亚单元:
Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3.
功能:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
亚细胞位置:
Lysosome membrane
Single-pass type I membrane protein
Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
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