Map2k1 (基因名), Dual specificity mitogen-activated protein kinase kinase 1 (蛋白名), MP2K1_MOUSE.
Mouse Map2k1/ Dual specificity mitogen-activated protein kinase kinase 1 Recombinant Protein
ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1, MAP kinase kinase 1, Mek1, Prkmk1
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3/ERK1 and RGS14. Forms heterodimers with KSR2 which further dimerize to form tetramers. Interacts with ARRB2, LAMTOR3, MAPK1/ERK2, RAF1, PPARG AND VRK2. Interacts with SGK1, BIRC6/bruce (By similarity). Interacts with KSR-1 (PubMed:10409742). Interacts with MORG1 (PubMed:15118098). Forms a heterodimer with MAP2K2/MEK2 (PubMed:19219045).
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Cytoplasm Cytoskeleton Microtubule organizing center Spindle pole body Cytoplasm Nucleus Membrane Peripheral membrane protein Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (By similarity). Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742).
MPKKKPTPIQ | LNPAPDGSAV | NGTSSAETNL | EALQKKLEEL | ELDEQQRKRL |
EAFLTQKQKV | GELKDDDFEK | ISELGAGNGG | VVFKVSHKPS | GLVMARKLIH |
LEIKPAIRNQ | IIRELQVLHE | CNSPYIVGFY | GAFYSDGEIS | ICMEHMDGGS |
LDQVLKKAGR | IPEQILGKVS | IAVIKGLTYL | REKHKIMHRD | VKPSNILVNS |
RGEIKLCDFG | VSGQLIDSMA | NSFVGTRSYM | SPERLQGTHY | SVQSDIWSMG |
LSLVEMAVGR | YPIPPPDAKE | LELLFGCHVE | GDAAETPPRP | RTPGRPLSSY |
GMDSRPPMAI | FELLDYIVNE | PPPKLPSGVF | SLEFQDFVNK | CLIKNPAERA |
DLKQLMVHAF | IKRSDAEEVD | FAGWLCSTIG | LNQPSTPTHA | ASI
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