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MMP2 (基因名), 72 kDa type IV collagenase (蛋白名), MMP2_HUMAN.
产品名称:

Human MMP2/ 72 kDa type IV collagenase Recombinant Protein
基质金属蛋白酶2/明胶酶A

货号:

R0100h

商标:
EIAab®
监管等级:
别名:

72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, TBE-1, MMP-2, CLG4A

序列号:
P08253
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human MMP2 Protein
规格 & 价格: cart
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Human MMP2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 16q12.2 by HGNC 16q12.2 by Entrez Gene 16q12.2 by Ensembl
MMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.


功能:
Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.


亚细胞位置:
Isoform 2 Cytoplasm Mitochondrion



[1].
"Estrogen receptor alpha and matrix metalloproteinase 2 polymorphisms and age-related maculopathy in older women."

[2].
"Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression."

[3].
"Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation."

[4].
"Linked common polymorphisms in the gelatinase a promoter are associated with diminished transcriptional response to estrogen and genetic fitness."

[5].
"Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor."

[6].
"A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity."

[7].
"Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection."

[8].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[9].
"Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia."

[10].
"A Large-scale genetic association study of esophageal adenocarcinoma risk."
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