Kirrel1 (GeneName), Kin of IRRE-like protein 1 (ProteinName), kirr1_mouse.
Mouse Kirrel1/ Kin of IRRE-like protein 1 ELISA Kit
Kin of irregular chiasm-like protein 1,Nephrin-like protein 1,Neph1,Kirrel
Natural and recombinant mouse Kin of IRRE-like protein 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
E2838m is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 30 (Kin of IRRE-like protein 1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Kin of IRRE-like protein 1. The ELISA analytical biochemical technique of the E2838m kit is based on Kin of IRRE-like protein 1 antibody-Kin of IRRE-like protein 1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Kin of IRRE-like protein 1 antigen targets in samples. The ELISA Kit is designed to detect native, recombinant, Kin of IRRE-like protein 1. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL1 glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylated with GRB2 (By similarity).
Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Cell membrane Single-pass type I membrane protein Predominantly located at podocyte slit diaphragm.
MTLESPSTRL | MTCQSSLLPE | KPRFLSQKMW | APHLVVAYLI | FVTLALALPG |
TQTRFSQEPA | DQTVVAGQR | AVLPCVLLNY | SGIVQWTKDG | LALGMGQGLK |
AWPRYRVVGS | ADAGQYNLEI | T DAELSDDA | SYECQATEAA | LRSRRAKLTV |
LIPPEETRID | GGPVILLQAG | TPYNLTCRAF | NA KPAATII | WFRDGTQQEG |
AVTSTELLKD | GKRETTISQL | LIEPTDLDIG | RVFTCRSMNE | AIP NGKETS |
IELDVHHPPT | VTLSIEPQTV | LEGERVIFTC | QATANPEILG | YRWAKGGFLI |
EDAH ESRYE | TNVDYSFFTE | PVSCEVYNKV | GSTNVSTLVN | VHFAPRIVVY |
PKPTTTDIGS | DVTLT CVWV | GNPPLTLTWT | KKDSNMVLSN | SNQLLLKSVT |
QADAGTYTCR | AIVPRIGVAE | REVPLY VNG | PPIISSEAVQ | FAVRGDGGKV |
ECFIGSTPPP | DRIAWAWKEN | FLEVGTLERY | TVERTNS GS | GVLSTLTINN |
VMEADFQTHY | NCTAWNSFGP | GTAIIQLEER | EVLPVGIIAG | ATIGAGIL V |
VFSFAALVFF | LYRRRKGSRK | DVTLRKLDIK | VETVNREPLT | MHSDREDDTA |
SISTATRVM | KAIYSSFKDD | VDLKQDLRCD | TIDTREEYEM | KDPTNGYYNV |
RAHEDRPSSR | AVLYADYRAP | GPTRFDGRP | SSRLSHSSGY | AQLNTYSRAP |
ASDYGTEPTP | SGPSAPGGTD | TTSQLSYENY | E KFNSHPFP | GAAGYPTYRL |
GYPQAPPSGL | ERTPYEAYDP | IGKYATATRF | SYTSQHSDYG | QR FQQRMQT |
This product has not yet been referenced specifically in any publications.
"Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"NEPH1 defines a novel family of podocin interacting proteins."
"Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1."
"Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN."
"The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics."
"Architecture of the human interactome defines protein communities and disease networks."
"The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery."
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