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Kirrel1 (GeneName), Kin of IRRE-like protein 1 (ProteinName), kirr1_mouse.
Product Name:

Mouse Kirrel1/ Kin of IRRE-like protein 1 ELISA Kit

 
Cat.#:

E2838m

Brand:
EIAab®
Regulatory Status:
Alternative:

Kin of irregular chiasm-like protein 1,Nephrin-like protein 1,Neph1,Kirrel

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.312-20ng/mL
Sensitivity:
0.156ng/mL
Specificity:
Natural and recombinant mouse Kin of IRRE-like protein 1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Research Area:
Development Biology
Product Overview:
E2838m is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 30 (Kin of IRRE-like protein 1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Kin of IRRE-like protein 1. The ELISA analytical biochemical technique of the E2838m kit is based on Kin of IRRE-like protein 1 antibody-Kin of IRRE-like protein 1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Kin of IRRE-like protein 1 antigen targets in samples. The ELISA Kit is designed to detect native, recombinant, Kin of IRRE-like protein 1. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Mouse Kirrel1 ELISA Kit
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Product Datasheets
Instruction:
MSDS:


General Annotation


Sub Unit:
Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL1 glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylated with GRB2 (By similarity).


Function:
Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.


Subcellular Location:
Cell membrane Single-pass type I membrane protein Predominantly located at podocyte slit diaphragm.


This product has not yet been referenced specifically in any publications.

[1].
"Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy."

[2].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[3].
"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."

[4].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[5].
"NEPH1 defines a novel family of podocin interacting proteins."

[6].
"Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1."

[7].
"Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN."

[8].
"The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics."

[9].
"Architecture of the human interactome defines protein communities and disease networks."

[10].
"The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery."
Sample Data
Sample Data
Sample Data
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