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首页  >  酶联免疫试剂盒  >  Rat Abcb4 ELISA Kit
Abcb4 (基因名), Phosphatidylcholine translocator ABCB4 (蛋白名), MDR3_RAT.
产品名称:

Rat Abcb4/ Phosphatidylcholine translocator ABCB4 ELISA Kit
多药耐药蛋白3

货号:

E10409r

商标:
EIAab®
监管等级:
别名:

ATP-binding cassette sub-family B member 4, Multidrug resistance protein 2, Multidrug resistance protein 3, P-glycoprotein 2, P-glycoprotein 3, Mdr2, Pgp3, Pgy2

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.061ng/mL
特异性:
Natural and recombinant rat Phosphatidylcholine translocator ABCB4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cardiovascular
Rat Abcb4 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤4.2%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤7.6%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

107

101-113

Plasma

109

103-115

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

94-104%

104-116%

81-91%

102-113%

EDTA plasma(n=5)

91-100%

97-106%

97-109%

115-125%

heparin plasma(n=5)

107-115%

 

82-91%

107-117%

102-112%

 

通用注释


亚单元:
Interacts with HAX1 (PubMed:15159385). May interact with RACK1.


功能:
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes. Required for proper phospholipid bile formation. Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner. May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane. In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts. Does not confer multidrug resistance.


亚细胞位置:
Cell membrane Multi-pass membrane protein Apical cell membrane Multi-pass membrane protein Membrane raft Cytoplasm Cytoplasmic vesicle Clathrin-coated vesicle Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules. Localized preferentially in lipid nonraft domains of canalicular plasma membranes. Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner. Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA-dependent manner.


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