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Abcb4 (GeneName), Multidrug resistance protein 2 (ProteinName), MDR2_MOUSE.
Product Name:

Mouse Abcb4/ Multidrug resistance protein 2 ELISA Kit

Cat.#:

E10409m

Brand:
EIAab®
Regulatory Status:
Alternative:

ATP-binding cassette sub-family B member 4, P-glycoprotein 2, Mdr2, Pgy-2, Pgy2

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.156-10ng/mL
Sensitivity:
0.088ng/mL
Specificity:
Natural and recombinant mouse Multidrug resistance protein 2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
Cardiovascular
Mouse Abcb4 ELISA Kit
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Mouse Abcb4 ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤8.0%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤10.0%

Recovery
Recovery was determined by spiking various levels of Multidrug resistance protein 2 into serum and plasma.

Sample Type

Average(%)

Recovery Range(%)

Serum

104

98-110

Plasma

106

100-112

 

 

 

 

Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Multidrug resistance protein 2 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample

1:2

1:4

1:8

1:16

serum(n=5)

98-110%

100-112%

94-106%

115-125%

EDTA plasma(n=5)

97-107%

100-110%

86-96%

108-119%

heparin plasma(n=5)

94-104%

 

103-112%

110-119%

95-104%

 

General Annotation


Sub Unit:
Interacts with HAX1.


Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Mouse MDR2 is not capable of conferring drug resistance.


Subcellular Location:
Membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"A new splicing site mutation of the ABCB4 gene in intrahepatic cholestasis of pregnancy with raised serum gamma-GT."

[2].
"Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury."

[3].
"Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11)."

[4].
"Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy."

[5].
"MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis."

[6].
"Common variants of ABCB4 and ABCB11 and plasma lipid levels: a study in sib pairs with gallstones, and controls."

[7].
"Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4."

[8].
"ABCB4 gene mutations and single-nucleotide polymorphisms in women with intrahepatic cholestasis of pregnancy."

[9].
"ABCB4 sequence variations in young adults with cholesterol gallstone disease."

[10].
"ABCB4 heterozygous gene mutations associated with fibrosing cholestatic liver disease in adults."
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