ABCG2 (GeneName), ATP-binding cassette sub-family G member 2 (ProteinName), ABCG2_BOVIN.
Bovine ABCG2/ ATP-binding cassette sub-family G member 2 ELISA Kit
Urate exporter, CD338
Natural and recombinant bovine ATP-binding cassette sub-family G member 2
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Monomer under reducing conditions, the minimal functional unit is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers.
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain.
Cell membrane Multi-pass membrane protein Mitochondrion membrane Multi-pass membrane protein
MSSNSYEVSI | PMSKKLNGIP | ETTSKDLQTL | TEGAVLSFHN | ICYRVKVKTG |
FLLCRKTIEK | EILANINGVM | KPGLNAILGP | TGGGKSSLLD | ILAARKDPHG |
LSGDVLINGA | PRPANFKCNS | GYVVQDDVVM | GTLTVRENLQ | FSAALRLPTT |
MTSYEKNERI | NKVIQELGLD | KVADSKVGTQ | FIRGVSGGER | KRTSIAMELI |
TDPSILFLDE | PTTGLDSSTA | NAVLLLLKRM | SKQGRTIIFS | IHQPRYSIFK |
LFDSLTLLAS | GRLMFHGPAQ | EALGYFGAIG | FRCEPYNNPA | DFFLDIINGD |
SSAVVLNRED | IGDEANETEE | PSKKDTPLIE | KLAEFYVNSS | FFKETKVELD |
KFSGDQRRKK | LPSYKEVTYA | TSFCHQLKWI | SRRSFKNLLG | NPQASIAQLI |
VTVFLGLVIG | AIFYDLKNDP | AGIQNRAGVL | FFLTTNQCFS | SVSAVELLVV |
EKKLFIHEYI | SGYYRVSSYF | FGKLLSDLLP | MRMLPSIIFT | CITYFLLGLK |
PKVEAFFIMM | LTLMMVAYSA | SSMALAIAAG | QSVVSIATLL | MTISFVFMMI |
FSGLLVNLKT | VVPWLSWLQY | LSIPRYGYAA | LQHNEFLGQN | FCPGLNVTTN |
NTCSYAICTG | EEFLTNQGID | ISPWGLWKNH | VALACMIVIF | LTIAYLKLLF |
This product has not yet been referenced specifically in any publications.
"Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation."
"ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin."
"Identification and functional characterization of breast cancer resistance protein in human bronchial epithelial cells (Calu-3)."
"Telmisartan pharmacokinetics in Japanese renal transplant recipients."
"Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2."
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