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ABCG2 (GeneName), ATP-binding cassette sub-family G member 2 (ProteinName), ABCG2_BOVIN.
Product Name:

Bovine ABCG2/ ATP-binding cassette sub-family G member 2 ELISA Kit

Cat.#:

E0960b

Brand:
EIAab®
Regulatory Status:
Alternative:

Urate exporter, CD338

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.78-50ng/ml
Sensitivity:
0.21ng/ml
Specificity:
Natural and recombinant bovine ATP-binding cassette sub-family G member 2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
Neurosciences
Bovine ABCG2 ELISA Kit
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Bovine ABCG2 ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


General Annotation


Sub Unit:
Monomer under reducing conditions, the minimal functional unit is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers.


Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain.


Subcellular Location:
Cell membrane Multi-pass membrane protein Mitochondrion membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation."

[2].
"ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin."

[3].
"Identification and functional characterization of breast cancer resistance protein in human bronchial epithelial cells (Calu-3)."

[4].
"Telmisartan pharmacokinetics in Japanese renal transplant recipients."

[5].
"Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2."
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