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ABCG2 (基因名), ATP-binding cassette sub-family G member 2 (蛋白名), abcg2_human.
产品名称:

Human ABCG2/ ATP-binding cassette sub-family G member 2 ELISA Kit
腺苷三磷酸结合盒转运蛋白G2

货号:

E0960h

商标:
EIAab®
监管等级:
别名:

Breast cancer resistance protein, CDw338, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter, Urate exporter, CD338, ABCP, BCRP, BCRP1, MXR

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.067ng/mL
特异性:
Natural and recombinant human ATP-binding cassette sub-family G member 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Neurosciences
Human ABCG2 ELISA Kit
规格 & 价格: cart
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Human ABCG2 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤3.8%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤7.2%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

107

101-113

Plasma

109

103-115

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

80-89%

80-90%

107-117%

105-115%

EDTA plasma(n=5)

108-117%

89-99%

102-114%

99-108%

heparin plasma(n=5)

91-101%

 

98-108%

82-91%

85-97%

 

通用注释


亚单元:
Monomer under reducing conditions, the minimal functional units is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers.


功能:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.


亚细胞位置:
Cell membrane Multi-pass membrane protein Mitochondrion membrane Multi-pass membrane protein


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