ABCC11 (GeneName), ATP-binding cassette sub-family C member 11 (ProteinName), ABCCB_HUMAN.
Human ABCC11/ ATP-binding cassette sub-family C member 11 ELISA Kit
Multidrug resistance-associated protein 8, MRP8
Natural and recombinant human ATP-binding cassette sub-family C member 11
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ATP-binding cassette sub-family C member 11 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Enhances the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689).
Cell membrane Multi-pass membrane protein Vacuole membrane Cytoplasmic vesicle membrane
MTRKRTYWVP | NSSGGLVNRG | IDIGDDMVSG | LIYKTYTLQD | GPWSQQERNP |
EAPGRAAVPP | WGKYDAALRT | MIPFRPKPRF | PAPQPLDNAG | LFSYLTVSWL |
TPLMIQSLRS | RLDENTIPPL | SVHDASDKNV | QRLHRLWEEE | VSRRGIEKAS |
VLLVMLRFQR | TRLIFDALLG | ICFCIASVLG | PILIIPKILE | YSEEQLGNVV |
HGVGLCFALF | LSECVKSLSF | SSSWIINQRT | AIRFRAAVSS | FAFEKLIQFK |
SVIHITSGEA | ISFFTGDVNY | LFEGVCYGPL | VLITCASLVI | CSISSYFIIG |
YTAFIAILCY | LLVFPLAVFM | TRMAVKAQHH | TSEVSDQRIR | VTSEVLTCIK |
LIKMYTWEKP | FAKIIEDLRR | KERKLLEKCG | LVQSLTSITL | FIIPTVATAV |
WVLIHTSLKL | KLTASMAFSM | LASLNLLRLS | VFFVPIAVKG | LTNSKSAVMR |
FKKFFLQESP | VFYVQTLQDP | SKALVFEEAT | LSWQQTCPGI | VNGALELERN |
GHASEGMTRP | RDALGPEEEG | NSLGPELHKI | NLVVSKGMML | GVCGNTGSGK |
SSLLSAILEE | MHLLEGSVGV | QGSLAYVPQQ | AWIVSGNIRE | NILMGGAYDK |
ARYLQVLHCC | SLNRDLELLP | FGDMTEIGER | GLNLSGGQKQ | RISLARAVYS |
DRQIYLLDDP | LSAVDAHVGK | HIFEECIKKT | LRGKTVVLVT | HQLQYLEFCG |
QIILLENGKI | CENGTHSELM | QKKGKYAQLI | QKMHKEATSD | MLQDTAKIAE |
KPKVESQALA | TSLEESLNGN | AVPEHQLTQE | EEMEEGSLSW | RVYHHYIQAA |
GGYMVSCIIF | FFVVLIVFLT | IFSFWWLSYW | LEQGSGTNSS | RESNGTMADL |
GNIADNPQLS | FYQLVYGLNA | LLLICVGVCS | SGIFTKVTRK | ASTALHNKLF |
NKVFRCPMSF | FDTIPIGRLL | NCFAGDLEQL | DQLLPIFSEQ | FLVLSLMVIA |
VLLIVSVLSP | YILLMGAIIM | VICFIYYMMF | KKAIGVFKRL | ENYSRSPLFS |
HILNSLQGLS | SIHVYGKTED | FISQFKRLTD | AQNNYLLLFL | SSTRWMALRL |
EIMTNLVTLA | VALFVAFGIS | STPYSFKVMA | VNIVLQLASS | FQATARIGLE |
TEAQFTAVER | ILQYMKMCVS | EAPLHMEGTS | CPQGWPQHGE | IIFQDYHMKY |
RDNTPTVLHG | INLTIRGHEV | VGIVGRTGSG | KSSLGMALFR | LVEPMAGRIL |
IDGVDICSIG | LEDLRSKLSV | IPQDPVLLSG | TIRFNLDPFD | RHTDQQIWDA |
LERTFLTKAI | SKFPKKLHTD | VVENGGNFSV | GERQLLCIAR | AVLRNSKIIL |
IDEATASIDM | ETDTLIQRTI | REAFQGCTVL | VIAHRVTTVL | NCDHILVMGN |
GKVVEFDRPE | VLRKKPGSLF | AALMATATSS | LR
This product has not yet been referenced specifically in any publications.
"Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)."
"MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine."
"Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12."
"A functional ABCC11 allele is essential in the biochemical formation of human axillary odor."
"Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?"
"Japanese map of the earwax gene frequency: a nationwide collaborative study by Super Science High School Consortium."
"A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene."
"A SNP in the ABCC11 gene is the determinant of human earwax type."
"MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer."
"Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12."
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