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Home  >  ELISA Kit  >  Human ABCC11 ELISA Kit
ABCC11 (GeneName), ATP-binding cassette sub-family C member 11 (ProteinName), ABCCB_HUMAN.
Product Name:

Human ABCC11/ ATP-binding cassette sub-family C member 11 ELISA Kit

Cat.#:

E9625h

Brand:
EIAab®
Regulatory Status:
Alternative:

Multidrug resistance-associated protein 8, MRP8

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.78-50ng/mL
Sensitivity:
0.39ng/mL
Specificity:
Natural and recombinant human ATP-binding cassette sub-family C member 11
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
-
Human ABCC11 ELISA Kit
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Human ABCC11 ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ATP-binding cassette sub-family C member 11 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample

1:2

1:4

1:8

1:16

serum(n=5)

84-92%

106-116%

96-106%

95-105%

EDTA plasma(n=5)

117-127%

108-117%

107-117%

87-96%

heparin plasma(n=5)

103-114%

 

110-120%

92-92%

105-115%

 

General Annotation


Sub Unit:
N/A


Function:
Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Enhances the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689).


Subcellular Location:
Cell membrane Multi-pass membrane protein Vacuole membrane Cytoplasmic vesicle membrane


This product has not yet been referenced specifically in any publications.

[1].
"Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)."

[2].
"MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine."

[3].
"Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12."

[4].
"A functional ABCC11 allele is essential in the biochemical formation of human axillary odor."

[5].
"Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?"

[6].
"Japanese map of the earwax gene frequency: a nationwide collaborative study by Super Science High School Consortium."

[7].
"A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene."

[8].
"A SNP in the ABCC11 gene is the determinant of human earwax type."

[9].
"MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer."

[10].
"Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12."
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