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Home  >  ELISA Kit  >  Mouse Abca7 ELISA Kit
Abca7 (GeneName), ATP-binding cassette sub-family A member 7 (ProteinName), ABCA7_MOUSE.
Product Name:

Mouse Abca7/ ATP-binding cassette sub-family A member 7 ELISA Kit

Cat.#:

E15004m

Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.156-10ng/mL
Sensitivity:
0.085ng/mL
Specificity:
Natural and recombinant mouse ATP-binding cassette sub-family A member 7
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
-
Mouse Abca7 ELISA Kit
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Mouse Abca7 ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤6.3%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤8.5%

Recovery
Recovery was determined by spiking various levels of ATP-binding cassette sub-family A member 7 into serum and plasma.

Sample Type

Average(%)

Recovery Range(%)

Serum

96

90-102

Plasma

98

92-104

 

 

 

 

Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ATP-binding cassette sub-family A member 7 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample

1:2

1:4

1:8

1:16

serum(n=5)

105-117%

104-115%

100-110%

117-127%

EDTA plasma(n=5)

97-105%

100-110%

104-113%

107-117%

heparin plasma(n=5)

92-102%

 

90-99%

104-116%

107-117%

 

General Annotation


Sub Unit:
N/A


Function:
Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.


Subcellular Location:
Cell membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Early endosome membrane Multi-pass membrane protein Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes (PubMed:16908670). Localizes to the apical brush border of cells in the proximal tubules of kidney (Probable).


This product has not yet been referenced specifically in any publications.

[1].
"Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein."

[2].
"Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)."

[3].
"Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease."

[4].
"Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study."

[5].
"Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease."

[6].
"Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease."

[7].
"Genetic susceptibility to distinct bladder cancer subphenotypes."

[8].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[9].
"Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease."

[10].
"Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China."
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