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AP (Shorten Name),
Product Name:

General AP/ Allopregnanolone ELISA Kit

 
Cat.#:

E1963Ge

Brand:
EIAab®
Regulatory Status:
Alternative:

3α,5α-tetrahydroprogesterone,3α-hydroxy-5α-pregnan-20-one

Detection Method:
ELISA
Assay Type:
Competitive
Detection Range:
31.2-2000pg/mL
Sensitivity:
9.5pg/mL
Specificity:
Natural and recombinant general Allopregnanolone
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Research Area:
-
Product Overview:
E1963Ge is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 30 (Allopregnanolone) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Allopregnanolone. The ELISA analytical biochemical technique of the E1963Ge kit is based on Allopregnanolone antibody-Allopregnanolone antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Allopregnanolone antigen targets in samples. The ELISA Kit is designed to detect native, recombinant, Allopregnanolone. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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General AP ELISA Kit
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Product Datasheets
Datasheet:
Instruction:
MSDS:


Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Allopregnanolone and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample

1:2

1:4

1:8

1:16

serum(n=5)

92-102%

105-114%

111-120%

86-96%

EDTA plasma(n=5)

99-108%

80-88%

99-109%

104-114%

heparin plasma(n=5)

97-107%

 

88-100%

101-110%

85-93%

 

General Annotation


Sub Unit:
N/A


Function:
Allopregnanolone (3α-hydroxy-5α-pregnan-20-one or 3α,5α-tetrahydroprogesterone) is a prototypic neurosteroid present in the blood and also the brain. It is a metabolite of progesterone and potent modulator of GABAA receptors. While allopregnanolone, like other GABAA receptor active neurosteroids such as allotetrahydrodeoxycorticosterone (3α,21-dihydroxy-5α-pregnan-20-one; THDOC), positively modulates all GABAA receptor isoforms, those isoforms containing δ-subunits exhibit greater magnitude potentiation. Allopregnanolone has pharmacological properties similar to other positive modulators of GABAA receptors, including anxiolytic and anticonvulsant activity.


Location:
N/A


Sample Data
Sample Data
Sample Data
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