AP (短名 ),
产品名称:
General AP/ Allopregnanolone CLIA Kit
别孕烯醇酮
货号:
U1963Ge
商标:
EIAab®
监管等级:
别名:
3α, 5α-tetrahydroprogesterone, 3α-hydroxy-5α-pregnan-20-one
检测方法:
CLIA
实验类型:
Competitive
检测范围:
3.9-250pg/mL
特异性:
Natural and recombinant general Allopregnanolone
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
N/A
功能:
Allopregnanolone (3α-hydroxy-5α-pregnan-20-one or 3α,5α-tetrahydroprogesterone) is a prototypic neurosteroid present in the blood and also the brain. It is a metabolite of progesterone and potent modulator of GABAA receptors. While allopregnanolone, like other GABAA receptor active neurosteroids such as allotetrahydrodeoxycorticosterone (3α,21-dihydroxy-5α-pregnan-20-one; THDOC), positively modulates all GABAA receptor isoforms, those isoforms containing δ-subunits exhibit greater magnitude potentiation. Allopregnanolone has pharmacological properties similar to other positive modulators of GABAA receptors, including anxiolytic and anticonvulsant activity.
Location:
N/A
[1].
"Resveratrol ameliorated the behavioral deficits in a mouse model of post-traumatic stress disorder"
ZS Zhang, ZK Qiu, JL He, et al.
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