首页 > 重组蛋白 > Human TRPV1 Recombinant Protein

TRPV1 (基因名), Transient receptor potential cation channel subfamily V member 1 (蛋白名), trpv1_human.

产品名称:

Human TRPV1/ Transient receptor potential cation channel subfamily V member 1 Recombinant Protein
瞬态电压感受器阳离子通道亚科V成员1

货号:

R12152h

商标:

EIAab^®

监管等级:

RUO

别名:

Capsaicin receptor, Osm-9-like TRP channel 1, Vanilloid receptor 1, OTRPC1, TrpV1, VR1

序列号:

Q8NER1

来源:

E.coli

种属:

Human

标签:

His

序列:

Recombinant protein

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Signal Transduction

规格 & 价格:

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Human TRPV1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 17p13.2 by HGNC 17p13.2 by Entrez Gene 17p13.2 by Ensembl

TRPV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with PIRT (By similarity). Homotetramer (By similarity). Interacts with TRPV3 and may also form a heteromeric channel with TRPV3 (PubMed:12077606). Interacts with CALM, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity). Interacts with TMEM100.

功能:

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.

亚细胞位置:

Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell projection Dendritic spine membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Mostly, but not exclusively expressed in postsynaptic dendritic spines.

数据库链接

UniGene:

Hs.579217

SMR:

Q8NER1

STRING:

9606.ENSP00000459962

KEGG:

hsa:7442

MIM:

602076

Pfam:

PF12796

Uniprot:

Q8NER1

相关产品

Mouse Trpv1 ELISA Kit

序列长度:

839

序列:

仅供参考，详细请咨询（services@eiaab.com）

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839:

SARDRQSAQP | EEVYLRQFSG | SLKPEDAEVF | KSPAASGEK

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures."

(PMID: 14987252)

[2].

"Molecular determinants of vanilloid sensitivity in TRPV1."

(PMID: 14996838)

[3].

"Pharmacological differences between the human and rat vanilloid receptor 1 (VR1)."

(PMID: 11226139)

[4].

"The tissue distribution and functional characterization of human VR1."

(PMID: 11243859)

[5].

"Cloning and functional expression of a human orthologue of rat vanilloid receptor-1."

(PMID: 11050376)

[6].

"The capsaicin receptor: a heat-activated ion channel in the pain pathway."

(PMID: 9349813)

[7].

"A Recurrent De Novo PACS2 Heterozygous Missense Variant Causes Neonatal-Onset Developmental Epileptic Encephalopathy, Facial Dysmorphism, and Cerebellar Dysgenesis."

(PMID: 29656858)

[8].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[9].

"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

(PMID: 20379614)

[10].

"Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma."

(PMID: 20639579)

[1].

人瞬态电压感受器阳离子通道亚科V成员1(TRPV1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人瞬态电压感受器阳离子通道亚科V成员1(TRPV1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人瞬态电压感受器阳离子通道亚科V成员1(TRPV1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人瞬态电压感受器阳离子通道亚科V成员1(TRPV1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人瞬态电压感受器阳离子通道亚科V成员1(TRPV1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人瞬态电压感受器阳离子通道亚科V成员1(TRPV1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人瞬态电压感受器阳离子通道亚科V成员1(TRPV1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人瞬态电压感受器阳离子通道亚科V成员1(TRPV1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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