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CASP1 (基因名), Caspase-1 (蛋白名), casp1_human.
产品名称:

CASP1 Antibody

货号:

P1592Rb-h

商标:
EIAab®
监管等级:
别名:

Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, p45, IL-1BC, ICE, CASP-1, IL1BC, IL1BCE

序列号:
P29466
反应性:
human
免疫原:
corresponding to a sequence mapping at the 120-297aa of P29466
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
Neurosciences
Human CASP1 Polyclonal Antibody
规格 & 价格: cart
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Human CASP1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
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R&D 技术数据
Immunohistochemical analysis of formalin-fixed paraffin embedded Human Mammary Cancer Tissue using CASP1 antibody.
通用注释


亚单元:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17/INCA and CARD18.


功能:
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.


亚细胞位置:
Cytoplasm



[1].
Chang-Nam Son, So-Young Bang, Ji Hae Kim, Chan-Bum Choi, Tae-Hwan Kim, and Jae-Bum Jun
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