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Sarm1 (基因名), Sterile alpha and TIR motif-containing protein 1 (蛋白名), sarm1_mouse.
产品名称:

Mouse Sarm1/ Sterile alpha and TIR motif-containing protein 1 ELISA Kit

货号:

E15733m

商标:
EIAab®
监管等级:
别名:

Tir-1 homolog, MyD88-5, Kiaa0524

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.039ng/mL
特异性:
Natural and recombinant mouse Sterile alpha and TIR motif-containing protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Mouse Sarm1 ELISA Kit
规格 & 价格: cart
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Mouse Sarm1 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function (By similarity). Interacts with SDC2 (via cytoplasmic domain) and MAPK10/JNK3.


功能:
Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38. Can restrict West Nile virus (WNV) pathogenesis.


亚细胞位置:
Cytoplasm Cell projection Axon Cell projection Dendrite Cell junction Synapse Mitochondrion Associated with microtubules.


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