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Lat (基因名), Linker for activation of T-cells family member 1 (蛋白名), lat_mouse.
产品名称:

Mouse Lat/ Linker for activation of T-cells family member 1 ELISA Kit
激活t细胞家族成员1

货号:

E0270m

商标:
EIAab®
监管等级:
别名:

36 kDa phospho-tyrosine adapter protein, p36-38, pp36

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
灵敏度:
40.3pg/mL
特异性:
Natural and recombinant mouse Linker for activation of T-cells family member 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Mouse Lat ELISA Kit
规格 & 价格: cart
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Mouse Lat ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB and SKAP2. Interacts with FCGR1A (By similarity). Interacts with CLNK. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes.


功能:
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.


亚细胞位置:
Cell membrane Single-pass type III membrane protein Present in lipid rafts.


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