Rat Lat/ Linker for activation of T-cells family member 1 CLIA Kit
激活t细胞家族成员1

货号:

U0270r

商标:

EIAab^®

监管等级:

RUO

别名:

36 kDa phospho-tyrosine adapter protein, p36-38, pp36

检测方法:

CLIA

特异性:

Natural and recombinant rat Linker for activation of T-cells family member 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Rat Lat CLIA Kit

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通用注释

亚单元:

When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK. Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes.

功能:

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

亚细胞位置:

Cell membrane Single-pass type III membrane protein Present in lipid rafts.

数据库链接

UniGene:

Rn.9773

STRING:

10116.ENSRNOP00000023563

KEGG:

rno:81511

Pfam:

PF15234

Uniprot: