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Ubqln4 (基因名), Ubiquilin-4 (蛋白名), UBQL4_MOUSE.
产品名称:

Mouse Ubqln4/ Ubiquilin-4 ELISA Kit
Ubiquilin-4

货号:

E12975m

商标:
EIAab®
监管等级:
别名:

Ataxin-1 interacting ubiquitin-like protein, Ataxin-1 ubiquitin-like-interacting protein A1U, Connexin43-interacting protein of 75 kDa, A1Up, CIP75, Cip75, Ubin

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.312-20ng/mL
灵敏度:
0.115ng/mL
特异性:
Natural and recombinant mouse Ubiquilin-4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Mouse Ubqln4 ELISA Kit
规格 & 价格: cart
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Mouse Ubqln4 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Homooligomer. Binds ATXN1/SCA1. Interaction with ATXN1 inhibits polyubiquitination of UBQLN4 and interferes with PSMD4 binding (By similarity). Interacts (via ubiquitin-like domain) with PSMD2 and PSMD4, regulatory subunits of the proteasome (PubMed:18079109). Binds signal sequences of proteins that are targeted to the endoplasmic reticulum (PubMed:11162551). Interacts (via UBA domain) with GJA1 (not ubiquitinated) and with ubiquitin; both compete for the same binding site (PubMed:18079109, PubMed:20940304, PubMed:20127391). Interacts (via UBA domain) with polyubiquitin chains and polyubiquitinated proteins (PubMed:20940304). Interacts with HERPUD1. Interacts (via ubiquitin-like domain) with UBQLN1 (via UBA domain). Interacts (via STI1 1 and 2 domains) with MAP1LC3A/B/C. Interacts with UBQLN2.


功能:
Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (By similarity). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (PubMed:18079109, PubMed:20940304). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion.


亚细胞位置:
Nucleus Cytoplasm Endoplasmic reticulum Cytoplasm Perinuclear region Cytoplasmic vesicle Autophagosome Colocalizes with the proteasome, both in nucleus and cytoplasm (By similarity).


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