首页 > 重组蛋白 > Human UBQLN4 Recombinant Protein

UBQLN4 (基因名), Ubiquilin-4 (蛋白名), ubql4_human.

产品名称:

Human UBQLN4/ Ubiquilin-4 Recombinant Protein
Ubiquilin-4

货号:

R12975h

商标:

EIAab^®

监管等级:

RUO

别名:

Ataxin-1 interacting ubiquitin-like protein, Ataxin-1 ubiquitin-like-interacting protein A1U, Connexin43-interacting protein of 75 kDa, A1Up, CIP75, C1orf6, CIP75, UBIN

序列号:

Q9NRR5

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human UBQLN4 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 1q22 by HGNC 1q22 by Entrez Gene 1q22 by Ensembl

UBQLN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homooligomer (Ref. 6). Binds signal sequences of proteins that are targeted to the endoplasmic reticulum. Interacts (via UBA domain) with GJA1 (not ubiquitinated) and with ubiquitin; both compete for the same binding site. Interacts (via UBA domain) with ubiquitin and with polyubiquitin chains. Interacts with PSMD2 (By similarity). Interacts (via ubiquitin-like domain) with PSMD4, a regulatory subunit of the 26S proteasome. Interacts with ATXN1/SCA1. Interaction with ATXN1 inhibits polyubiquitination of UBQLN4 and interferes with PSMD4 binding. Interacts with HERPUD1. Interacts (via ubiquitin-like domain) with UBQLN1 (via UBA domain). Interacts (via STI1 1 and 2 domains) with MAP1LC3A/B/C. Interacts with UBQLN2.

功能:

Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205).

亚细胞位置:

Nucleus Cytoplasm Endoplasmic reticulum Cytoplasm Perinuclear region Cytoplasmic vesicle Autophagosome Colocalizes with the proteasome, both in nucleus and cytoplasm.

数据库链接

UniGene:

Hs.283739

SMR:

Q9NRR5

STRING:

9606.ENSP00000357292

KEGG:

hsa:56893

MIM:

605440

Pfam:

PF00627

Uniprot:

Q9NRR5

相关产品

Mouse Ubqln4 ELISA Kit

Mouse Ubqln4 CLIA Kit

Mouse Ubqln4 Protein

Mouse Ubqln4 Polyclonal Antibody

Mouse Ubqln4 Monoclonal Antibody

序列长度:

601

序列:

仅供参考，详细请咨询（services@eiaab.com）

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3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein."

(PMID: 11001934)

[2].

"The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up."

(PMID: 15280365)

[3].

"Identification of two paralogous regions mapping to the short and long arms of human chromosome 2 comprising LIS1 pseudogenes."

(PMID: 10575211)

[4].

"Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery."

(PMID: 23459205)

[5].

"Herp enhances ER-associated protein degradation by recruiting ubiquilins."

(PMID: 18307982)

[6].

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

(PMID: 15489334)

[7].

"The UbL-UBA Ubiquilin4 protein functions as a tumor suppressor in gastric cancer by p53-dependent and p53-independent regulation of p21."

(PMID: 29899380)

[8].

"Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells."

(PMID: 29509190)

[9].

"Overexpression of the Ubiquilin-4 (UBQLN4) is Associated with Cell Cycle Arrest and Apoptosis in Human Normal Gastric Epithelial Cell Lines GES-1 Cells by Activation of the ERK Signaling Pathway."

(PMID: 29807370)

[10].

"Nuclear export of ubiquitinated proteins via the UBIN-POST system."

(PMID: 29666234)

[1].

人Ubiquilin-4(UBQLN4)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人Ubiquilin-4(UBQLN4)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人Ubiquilin-4(UBQLN4)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人Ubiquilin-4(UBQLN4)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人Ubiquilin-4(UBQLN4)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人Ubiquilin-4(UBQLN4)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人Ubiquilin-4(UBQLN4)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人Ubiquilin-4(UBQLN4)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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