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Dvl1 (基因名), Segment polarity protein dishevelled homolog DVL-1 (蛋白名), DVL1_MOUSE.
产品名称:

Mouse Dvl1/ Segment polarity protein dishevelled homolog DVL-1 ELISA Kit
散乱蛋白

货号:

E15104m

商标:
EIAab®
监管等级:
别名:

DSH homolog 1, Dishevelled-1, Dvl

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
15.6-1000pg/mL
灵敏度:
7.85pg/mL
特异性:
Natural and recombinant mouse Segment polarity protein dishevelled homolog DVL-1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Mouse Dvl1 ELISA Kit
规格 & 价格: cart
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Mouse Dvl1 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: 0
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: 0
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

80

80-80

Plasma

80

80-80

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

110-120%

112-122%

86-98%

110-120%

EDTA plasma(n=5)

105-115%

96-109%

103-103%

92-101%

heparin plasma(n=5)

80-90%

 

95-107%

84-93%

106-116%

 

通用注释


亚单元:
Interacts with CXXC4 (By similarity). Interacts (via PDZ domain) with TMEM88 (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts (via PDZ domain) with NXN. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Interacts with CYLD. Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site. Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering. Interacts with DCDC2. Interacts with FOXK2.


功能:
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).


亚细胞位置:
Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Cytosol Cytoplasmic vesicle Localizes at the cell membrane upon interaction with frizzled family members.


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