首页 > 重组蛋白 > Human DVL1 Recombinant Protein

DVL1 (基因名), Segment polarity protein dishevelled homolog DVL-1 (蛋白名), dvl1_human.

产品名称:

Human DVL1/ Segment polarity protein dishevelled homolog DVL-1 Recombinant Protein
散乱蛋白

货号:

R15104h

商标:

EIAab^®

监管等级:

RUO

别名:

DSH homolog 1, Dishevelled-1

序列号:

O14640

来源:

E.coli

种属:

Human

标签:

His

序列:

Recombinant protein

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human DVL1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 1p36.33 by HGNC 1p36.33 by Entrez Gene 1p36.33 by Ensembl

DVL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD (By similarity). Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site (By similarity). Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering (By similarity). Interacts (via PDZ domain) with TMEM88. Interacts with DCDC2. Interacts with FOXK2 (PubMed:25805136).

功能:

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).

亚细胞位置:

Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Cytosol Cytoplasmic vesicle Localizes at the cell membrane upon interaction with frizzled family members.

数据库链接

UniGene:

Hs.731450

SMR:

O14640

STRING:

9606.ENSP00000368169

KEGG:

hsa:1855

MIM:

601365

Pfam:

PF00610

Uniprot:

O14640

相关产品

序列长度:

695

序列:

仅供参考，详细请咨询（services@eiaab.com）

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695:

YTVVGGPPGG | PPVRELAAVP | PELTGSRQSF | QKAMGNPCEF | FVDIM

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease."

(PMID: 11803455)

[2].

"beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins."

(PMID: 11742073)

[3].

"DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling."

(PMID: 25557784)

[4].

"Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome."

(PMID: 25817014)

[5].

"DVL1 frameshift mutations clustering in the penultimate exon cause autosomal-dominant Robinow syndrome."

(PMID: 25817016)

[6].

"Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia."

(PMID: 20634891)

[7].

"Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein."

(PMID: 21044957)

[8].

"High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men."

(PMID: 19453261)

[9].

"Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein."

(PMID: 19465938)

[10].

"Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling."

(PMID: 19956716)

[1].

人散乱蛋白(DVL1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人散乱蛋白(DVL1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人散乱蛋白(DVL1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人散乱蛋白(DVL1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人散乱蛋白(DVL1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人散乱蛋白(DVL1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人散乱蛋白(DVL1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人散乱蛋白(DVL1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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