Mouse Vcl/ Vinculin CLIA Kit

货号:

U1839m

商标:

EIAab^®

监管等级:

RUO

别名:

Metavinculin

检测方法:

CLIA

特异性:

Natural and recombinant mouse Vinculin

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cardiovascular

规格 & 价格:

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通用注释

亚单元:

Exhibits self-association properties. Interacts with APBB1IP, NRAP and TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin (By similarity). Interacts with SORBS1 (PubMed:10085297). Interacts with SYNM (By similarity). Interacts with CTNNA1 (By similarity). Binds to ACTN4; this interaction triggers conformational changes.

功能:

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

亚细胞位置:

Cell membrane Peripheral membrane protein Cytoplasmic side Cell junction Adherens junction Cell junction Focal adhesion Cytoplasm Cytoskeleton Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.

数据库链接

UniGene:

Mm.279361

SMR:

Q64727

STRING:

10090.ENSMUSP00000022369

KEGG:

mmu:22330

Pfam:

PF01044

Uniprot: