Human VCL/ Vinculin CLIA Kit

货号:

U1839h

商标:

EIAab^®

监管等级:

RUO

别名:

Metavinculin, MV

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

0.195-12.5ng/mL

特异性:

Natural and recombinant human Vinculin

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cardiovascular

规格 & 价格:

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Human VCL CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
序列 / 3D
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通用注释

亚单元:

Exhibits self-association properties. Interacts with APBB1IP and NRAP (By similarity). Interacts with TLN1. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin (By similarity). Interacts with SYNM. Interacts with SORBS1 (By similarity). Interacts with CTNNA1 (PubMed:26691986). Binds to ACTN4; this interaction triggers conformational changes (PubMed:15988023).

功能:

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

亚细胞位置:

Cell membrane Peripheral membrane protein Cytoplasmic side Cell junction Adherens junction Cell junction Focal adhesion Cytoplasm Cytoskeleton Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.

数据库链接

UniGene:

Hs.643896

SMR:

P18206

STRING:

9606.ENSP00000211998

KEGG:

hsa:7414

MIM:

193065

Pfam: