VCL (基因名), Vinculin (蛋白名), vinc_chick.
通用注释
亚单元:
Exhibits self-association properties. Interacts with APBB1IP, NRAP and TLN1. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin.
功能:
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
亚细胞位置:
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Cell junction
Adherens junction
Cell junction
Focal adhesion
Cytoplasm
Cytoskeleton
Recruitment to cell-cell junctions occurs in a myosin II-dependent manner (PubMed:20584916). Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (PubMed:20086044).
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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