Human KISS1/ Metastasis-suppressor KiSS-1 CLIA Kit
肿瘤转移抑制基因KISS-1

货号:

U2063h

商标:

EIAab^®

监管等级:

RUO

别名:

Kisspeptin-1, PP5098

检测方法:

CLIA

特异性:

Natural and recombinant human Metastasis-suppressor KiSS-1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Human KISS1 CLIA Kit

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通用注释

亚单元:

N/A

功能:

Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.95008

SMR:

Q15726

STRING:

9606.ENSP00000356162

KEGG:

hsa:3814

MIM: