Human IFNAR1/ Interferon alpha/beta receptor 1 CLIA Kit
干扰素α/β受体1

货号:

U1425h

商标:

EIAab^®

监管等级:

RUO

别名:

Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, Type I interferon receptor 1, CRF2-1, IFN-R-1, IFNAR

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

19.5-1250pg/mL

特异性:

Natural and recombinant human Interferon alpha/beta receptor 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Immunology

规格 & 价格:

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Human IFNAR1 CLIA Kit

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

Heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466 (PubMed:9121453). Interacts with TYK2 (PubMed:7526154, PubMed:15337770, PubMed:24704786). Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:14532120, PubMed:15337770, PubMed:18056411). Interacts with SHMT2; this promotes interaction with FAM175B and the BRISC complex (PubMed:24075985).

功能:

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

亚细胞位置:

Isoform 1 Cell membrane Single-pass type I membrane protein Late endosome Lysosome Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.

数据库链接

UniGene:

Hs.529400

SMR:

P17181

STRING:

9606.ENSP00000270139

KEGG:

hsa:3454

MIM:

107450

Pfam: