IFNAR1 (基因名), Interferon alpha/beta receptor 1 (蛋白名), inar1_bovin.
产品名称:
Bovine IFNAR1/ Interferon alpha/beta receptor 1 CLIA Kit
干扰素α/β受体1
货号:
U1425b
商标:
EIAab®
监管等级:
别名:
Type I interferon receptor 1, IFN-R-1, IFNAR
检测方法:
CLIA
特异性:
Natural and recombinant bovine Interferon alpha/beta receptor 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Immunology
通用注释
亚单元:
Heterodimer with IFNAR2. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-467. Interacts with TYK2. Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Interacts with SHMT2; this promotes interaction with FAM175B and the BRISC complex.
功能:
Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:8318540). Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.
亚细胞位置:
Cell membrane
Single-pass type I membrane protein
Late endosome
Lysosome
Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.
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