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Ifit1 (基因名), Interferon-induced protein with tetratricopeptide repeats 1 (蛋白名), ifit1_mouse.

产品名称:

Mouse Ifit1/ Interferon-induced protein with tetratricopeptide repeats 1 CLIA Kit
带肽重复序列结构域1的干扰素诱导表达蛋白

货号:

U14985m

商标:

EIAab^®

监管等级:

RUO

别名:

Glucocorticoid-attenuated response gene 16 protein, Interferon-induced 56 kDa protein, GARG-16, IFI-56K, IFIT-1, Garg16, Ifi56, Isg56

检测方法:

CLIA

特异性:

Natural and recombinant mouse Interferon-induced protein with tetratricopeptide repeats 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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通用注释

亚单元:

Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT2 and IFIT3 (By similarity). Interacts with EIF3E (By similarity). Interacts (via TPR repeats 1-4) with RPL15 (By similarity). Interacts with TMEM173/MITA and disrupts its interaction with MAVS or TBK1 (By similarity). Interacts with EIF3C. Interacts (via TPR repeats 4-7) with EEF1A1.

功能:

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism).

亚细胞位置:

Cytoplasm

数据库链接

UniGene:

Mm.439751

SMR:

Q64282

STRING:

10090.ENSMUSP00000099888

KEGG:

mmu:15957

Pfam: