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IFIT1 (基因名), Interferon-induced protein with tetratricopeptide repeats 1 (蛋白名), ifit1_human.

产品名称:

Human IFIT1/ Interferon-induced protein with tetratricopeptide repeats 1 CLIA Kit
带肽重复序列结构域1的干扰素诱导表达蛋白

货号:

U14985h

商标:

EIAab^®

监管等级:

RUO

别名:

Interferon-induced 56 kDa protein, IFI-56K, IFIT-1, G10P1, IFI56, IFNAI1, ISG56

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

19.5-1250pg/mL

特异性:

Natural and recombinant human Interferon-induced protein with tetratricopeptide repeats 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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产品说明书

说明书:

MSDS:

在线询价

数据
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序列 / 3D
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通用注释

亚单元:

Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts with EIF3C (By similarity). Interacts with IFIT2 and IFIT3. Interacts (via TPR repeats 1-4) with RPL15. Interacts with TMEM173/MITA and disrupts its interaction with MAVS or TBK1. Interacts with EIF3E. Interacts (via TPR repeat 2) with E1 proteins of HPV types 11, 18 and 3 and this interaction blocks E1 helicase activity and viral replication.

功能:

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.

亚细胞位置:

Cytoplasm

数据库链接

UniGene:

Hs.20315

SMR:

P09914

STRING:

9606.ENSP00000360869

KEGG:

hsa:3434

MIM: