Human IDO1/ Indoleamine 2,3-dioxygenase 1 CLIA Kit
吲哚胺2,3-双加氧酶1

货号:

U1547h

商标:

EIAab^®

监管等级:

RUO

别名:

Indoleamine-pyrrole 2, 3-dioxygenase, IDO-1, IDO, INDO

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

0.2-12.5ng/mL

特异性:

Natural and recombinant human Indoleamine 2,3-dioxygenase 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cell Biology

规格 & 价格:

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Human IDO1 CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Monomer.

功能:

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885).

亚细胞位置:

Cytoplasm Cytosol

数据库链接

UniGene:

Hs.840

SMR:

P14902

STRING:

9606.ENSP00000430505

KEGG:

hsa:3620

MIM: