Gabbr2 (基因名), Gamma-aminobutyric acid type B receptor subunit 2 (蛋白名), gabr2_rat.
产品名称:
Rat Gabbr2/ Gamma-aminobutyric acid type B receptor subunit 2 CLIA Kit
货号:
U12296r
商标:
EIAab®
监管等级:
别名:
G-protein coupled receptor 51, GABA-B receptor 2, Gpr51
检测方法:
CLIA
特异性:
Natural and recombinant rat Gamma-aminobutyric acid type B receptor subunit 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cell Biology
通用注释
亚单元:
Heterodimer of GABBR1 and GABBR2. Homodimers may form, but are inactive. Interacts with ATF4 via its C-terminal region.
功能:
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Cell junction
Synapse
Postsynaptic cell membrane
Multi-pass membrane protein
Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane.
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