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GABBR2 (基因名), Gamma-aminobutyric acid type B receptor subunit 2 (蛋白名), gabr2_human.

产品名称:

Human GABBR2/ Gamma-aminobutyric acid type B receptor subunit 2 CLIA Kit

货号:

U12296h

商标:

EIAab^®

监管等级:

RUO

别名:

G-protein coupled receptor 51, HG20, GABA-B receptor 2, GPR51, GPRC3B

检测方法:

CLIA

特异性:

Natural and recombinant human Gamma-aminobutyric acid type B receptor subunit 2

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cell Biology

规格 & 价格:

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通用注释

亚单元:

Heterodimer of GABBR1 and GABBR2. Homodimers may form, but are inactive. Interacts with ATF4 via its C-terminal region.

功能:

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

亚细胞位置:

Cell membrane Multi-pass membrane protein Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane.

数据库链接

UniGene:

Hs.198612

SMR:

O75899

STRING:

9606.ENSP00000259455

KEGG:

hsa:9568

MIM:

607340

Pfam: