Gabbr1 (基因名), Gamma-aminobutyric acid type B receptor subunit 1 (蛋白名), gabr1_rat.
产品名称:
Rat Gabbr1/ Gamma-aminobutyric acid type B receptor subunit 1 CLIA Kit
γ氨基丁酸B型受体亚型1
货号:
U2151r
商标:
EIAab®
监管等级:
别名:
GABA-B receptor 1
检测方法:
CLIA
特异性:
Natural and recombinant rat Gamma-aminobutyric acid type B receptor subunit 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cell Biology
通用注释
亚单元:
Heterodimer of GABBR1 and GABBR2. Homodimers may form, but are inactive. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1.
功能:
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Cell junction
Synapse
Postsynaptic cell membrane
Multi-pass membrane protein
Cell projection
Dendrite
Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. Colocalizes with ATF4 in hippocampal neuron dendritic membranes.
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