Eef1a1 (基因名), Elongation factor 1-alpha 1 (蛋白名), ef1a1_mouse.
产品名称:
Mouse Eef1a1/ Elongation factor 1-alpha 1 CLIA Kit
延长因子1-α1
货号:
U11476m
商标:
EIAab®
监管等级:
别名:
Elongation factor Tu, Eukaryotic elongation factor 1 A-1, EF-Tu, eEF1A-1, EF-1-alpha-1, Eef1a
检测方法:
CLIA
特异性:
Natural and recombinant mouse Elongation factor 1-alpha 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Epigenetics
通用注释
亚单元:
Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1, TXK, XPO5 and KARS (By similarity). May interact with ERGIC2 (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation (By similarity). Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner (By similarity). Interacts with IFIT1 (via TPR repeats 4-7).
功能:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
亚细胞位置:
Cytoplasm
Nucleus
Nucleus
Nucleolus
Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens (By similarity).
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